Author/Authors :
Ganim Ramadan, Mohamed Abdulhamid Department of Genetics and Bioengineering- Kastamonu University, turkey , Baloglu, Mehmet Cengiz Department of Genetics and Bioengineering- Kastamonu University, turkey , Altunoglu, Yasemin Celik Department of Genetics and Bioengineering- Kastamonu University, turkey , Kandemirli, Fatma Department of Biomedical Engineering - Kastamonu University, turkey , Burhan, Hakan Sen Research Group - Department of Biochemistry - Faculty of Arts and Science - Dumlupınar University, Evliya Çelebi Campus, Turkey , Aygün, Ayşenur Sen Research Group - Department of Biochemistry - Faculty of Arts and Science - Dumlupınar University, Evliya Çelebi Campus, Turkey , Sayiner, Hakan Sezgin Department of Infectious Diseases - Faculty of Medicine - Adiyaman University, Adiyaman, Turkey , Ozyigit, Filiz Department of Medical Sciences - Faculty of Medicine - Kutahya University of Health Sciences, turkey , Şen, Fatih Sen Research Group - Department of Biochemistry - Faculty of Arts and Science - Dumlupınar University, Evliya Çelebi Campus, Turkey
Abstract :
Isatin based materials can exhibit a wide range of biological activities
including antimicrobial, antiviral, antifungal, anthelmintic, antitumor,
anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant,
antitubercular, analgesic, and central nervous system depressant
activities. In this study, four compounds containing 5-Fluoro-isatin
thiosemicarbazone with methoxyphenyl or methoxyphenyl in different
positions and zinc complexes were evaluated based on their biological
activities. Compound 2 was the strongest compound affecting gramnegative
bacteria compared to the other compounds. Also, this compound
indicated better antimicrobial activity than positive control antibiotics.
Besides, compound 3 was the only compound that inhibited the growth
of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and
Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone
and its derivatives also showed DNA protection property from moderate to
good protections. Among them, compound 4 displayed the highest DNA
binding affinity. These compounds possessed a capacity for utilization as
drugs or drug additives based on their effects on bacteria strains and DNA
binding affinity.
Keywords :
5-Fluoro-Isatin , Antimicrobial activity , DNA protection , Thiosemicarbazone
