Title of article :
DISTRIBUTION AND CLINICOPATHOLOGICAL FEATURES OF BREAST CANCER HISTOLOGICAL SUBTYPES IN LATVIA
Author/Authors :
Srebnijs, Andrejs University of Latvia - Faculty of Medicine, LATVIA , Srebnijs, Andrejs Rîga East Clinical University Hospital - Latvian Oncology Centre, LATVIA , Isajevs, Sergejs University of Latvia - Faculty of Medicine, LATVIA , Isajevs, Sergejs Rîga East Clinical University Hospital - Centre of Pathology, LATVIA , Eglîtis, Jânis University of Latvia - Faculty of Medicine, LATVIA , Eglîtis, Jânis Rîga East Clinical University Hospital - Latvian Oncology Centre, LATVIA , Krûmins, Viesturs Rîga East Clinical University Hospital - Latvian Oncology Centre, LATVIA , Berzins, Juris University of Latvia - Faculty of Medicine, LATVIA , Vikmanis, Uldis University of Latvia - Faculty of Medicine, LATVIA
From page :
14
To page :
19
Abstract :
Breast cancer is a heterogenous disease. It consists of several histological subtypes that can be separated by morphology and immunohistochemistry. The aim of our study was to determine the distribution of breast cancer histological and molecular subtypes, and their relationship with clini- cal and pathological characteristics. A total of 561 patients who underwent breast carcinoma sur- gical treatment from January 2003 till December 2012 were enrolled in the study. In total, invasive ductal carcinomas not otherwise specified (IDC-NOS) plus invasive ductal carcinomas no special type (IDC-NST) were observed in 430 patients (76.65% of cases), medullar carcinoma in 14 pa- tients (2.45%), other rare ductal carcinoma subtypes in 13 patients (2.31%), lobular carcinoma in 81 patients (14.4%) and tubulolobular carcinoma in 23 patients (4.19%). Ductal carcinoma, lobular and tubulolobular carcinoma had predominantly luminal A and B subtype, whereas medullar carcinoma had HER2- positive and triple-negative (TN) subtype. Tubular, cribriform, mucinous, papillary, and apocrine carcinomas had predominantly luminal A subtype. Significant differences between breast cancer histological subtypes and clinicopathological characteristics were observed. Our study for the first time reported the distribution and characteristics of breast cancer histological subtypes in Latvian women and relationship to clinical and tumour histopathological characteristics.
Keywords :
breast cancer , histological subtypes , molecular subtypes , clinicopathological characteristics.
Journal title :
Proceedings of the Latvian Academy of Sciences. Section B Natural, Exact and Applied Sciences
Journal title :
Proceedings of the Latvian Academy of Sciences. Section B Natural, Exact and Applied Sciences
Record number :
2559001
Link To Document :
بازگشت