Title of article
Soursop (Anona muricata L.): Blood hematology and serum biochemistry of Sprague-Dawley rats
Author/Authors
Syahida, M. Malaysian Agriculture Research and Development Institute (MARDI) - Food Technology Research Centre, Malaysia , Syahida, M. Universiti Kebangsaan Malaysia - Faculty of Science and Technology, School of Chemical Sciences and Food Technology - Food Science Program, Malaysia , Maskat, M. Y. Universiti Kebangsaan Malaysia - Faculty of Science and Technology, School of Chemical Sciences and Food Technology - Food Science Program, Malaysia , Suri, R. Malaysian Agriculture Research and Development Institute (MARDI) - Food Technology Research Centre, Malaysia , Mamot, S. Universiti Kebangsaan Malaysia - Faculty of Science and Technology, School of Chemical Sciences and Food Technology - Food Science Program, Malaysia , Hadijah, H. Malaysian Agriculture Research and Development Institute (MARDI) - Food Technology Research Centre, Malaysia
From page
955
To page
959
Abstract
This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study, Annona muricata L. extract was dosed at 0 (CD, control dose), 0.5 (LD, low dose), 1.0 (MD, medium dose), 2.0g/kg (HD, high dose) body weight. For control group, distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p 0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.
Keywords
Soursop , blood hematology , serum biochemistry , Sprague , Dawley
Journal title
International Food Research Journal
Journal title
International Food Research Journal
Record number
2560205
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