Inhibitory effect of alkaloids of Albizia amara and Albizia saman on growth and fumonisin B1 production by Fusarium verticillioides

The investigation was aimed to evaluate the antifungal and antifumonisin activities of budmunchiamine A and pithecolobine against Fusarium verticillioides. The budmunchiamine A was isolated from Albizia amara and pithecolobine from Albizia saman. The results demonstrated that both budmunchiamine A and pithecolobine significantly inhibited the growth and fumonisin B1 production by F. verticillioides in a dose dependent manner. The MIC and MFC values ranged from 0.125 to 0.25 mg/ml and 0.25 to 0.5 mg/ml, respectively. In vitro evaluation showed that the fumonisin B1 production was completely inhibited by budmunchiamine A and pithecolobine at 0.25 mg/ml and 0.5 mg/ml, while in vivo evaluation showed complete inhibition at 0.25 g/kg and 0.5 g/kg, respectively. The present findings indicate the possible use of budmunchiamine A and pithecolobine as alternative agents to control the fungal and mycotoxin contaminations in food grains.