Title of article :
Antibacterial Activity of Short-Chained 1-Alkyl-3-methylimidazolium Bis(trifluoromethylsulfonyl) Imide Ionic Liquids
Author/Authors :
Jalal, R. ferdowsi university of mashhad - Faculty of Sciencesb, Institute of Biotechnology - Deparrment of Chemistry, Cell and Molecular Biotechnology Research Group, مشهد, ايران , Goharshadi, E.K. ferdowsi university of mashhad - Faculty of Sciences, Center of Nano Research - Department of Chemistry, مشهد, ايران , Sajjadi, S.H. university of tehran - Department of Chemistry, تهران, ايران , Nancarrow, P. American University of Sharjah - Department of Chemical Engineering, UAE
Abstract :
The antibacterial activity of a series of ionic liquids containing short-chained 1-alkyl-3-methylimidazolium cations ([Cnmim+]; n = 2, 4, 6 and 8) and bis (trifluoromethylsulfonyl) imide anion ([Tf2N]) against E. coli and B. subtilis was measured, for the first time. All ILs used in this work were synthesized and analyzed by Fourier transform infrared (FT-IR) spectroscopy, NMR, and Karl-Fischer titration. Antimicrobial activity was determined by the tube dilution method. The ILs investigated showed antibacterial activity against E. coli and B. subtilis. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were in the ranges of 0.041- 6.39 mM and 0.67-12.78 mM, respectively. The antibacterial activity for ionic liquids with longer alkyl chain (n ≥ 4) increased with increasing alkyl chain length. The highest inhibition against E. coli was found for [C8mim][Tf2N] (MIC = 0.041 mM and MBC = 0.67 mM). The mechanism of action of these ionic liquids was bacteriostatic.
Keywords :
Ionic liquid , Antibacterial activity , Imidazolium salts , Bis (trifluoromethylsulfonyl) imide
Journal title :
Physical Chemistry Research
Journal title :
Physical Chemistry Research
