Author/Authors :
Kalász, Huba Department of Pharmacology and Pharmacotherapy - Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary , Thuróczy, Julianna Animal Health Center Budafok - H-1221 Budapest, Kossuth Lajos Str. 52. Hungary , Karvaly, Gellért Department of Laboratory Medicine - Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary , Balogh, Lajos National “FJC” Research Institute for Radiobiology and Radiohigiene, H-1221 Budapest, Anna Str. 5. Hungary , Gyertyán, István Department of Pharmacology and Pharmacotherapy - Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary , Tóth-Molnár, Edit Department of Ophthalmology - University of Szeged, 6720 Szeged, Korányi fasor 10- 11, Hungary , Adeghate, Ernest Department of Anatomy - United Arab Emirates University, P.O.Box 17666, Al Ain, United Arab Emirates , Tekes, Kornélia Department of Pharmacodynamics - Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary
Abstract :
Background:
Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.
Objective:
Scouting special and beneficial side effects of selegiline treatment.
Method:
Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment.
Results:
Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.
Conclusion:
Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.
Keywords :
Selegiline , Aged-rats , Semen , Dopamine , Testis , Sperm , Testosterone , Cortisol
