Chemical Constituents from Garcinia maingayi and Garcinia parvifolia (Guttiferae) and Their Biological Activities

Detail chemical studies on Carcinia maingayi have yielded one xanthone, 1,3,7-trihydroxy2-( 3-methylbut-2-enyI)-xanthone, one benzophenone, isoxanthochymol, one benzoic acid derivative 3,4-dihydroxy-methylbenzoate and two triterpenoids, stigmasterol and sitosterol. Meanwhile, investigations on Garcinia parvifolia have afforded one triterpenoid, a-amyrin and two xanthones, cowanin and rubraxanthone. Their structures were derived based on spectroscopic evidence, mainly 1D and 2D NMR spectroscopy. Acetylation reaction was carried out on rubraxanthone to yield triacetate rubraxanthone. It was found that the pure rubraxanthone was strongly active against the larvae of Aedes aegypti with LC50 value of 15.49 μg/ml and HL-60 cells line with an IC50 value of 7.5 μg/ml.