Title of article
Adenoviral based Gene Therapy for Cancer in Human and Animals: A Review
Author/Authors
Tan, Seok Shin Universiti Putra Malaysia - Faculty of Veterinary Medicine - Department of Veterinary Pathology and Microbiology, Malaysia , Allaudin, Zeenathul Nazariah Universiti Putra Malaysia - Faculty of Veterinary Medicine - Department of Veterinary Pathology and Microbiology, Malaysia , Mohd. Lila, Mohd. Azmi Universiti Putra Malaysia - Faculty of Veterinary Medicine - Department of Veterinary Pathology and Microbiology, Malaysia
From page
129
To page
140
Abstract
Adenovirus vector is the most common used vector in clinical gene therapy. The development of adenovirus from the first generation until the helper-dependent adenovirus vector has greatly reduced toxicity and immunogenicity. The helper-dependent adenovirus can also prolong transgene expression. Tissue- or disease-specific approach has been used to improve the specificity of adenoviral vector for cancer gene therapy. This review summarizes some adenoviral gene therapy and targeting approaches available for human cancer as well as animal cancer
Keywords
Adenovirus vector , clinical , gene therapy , human cancer , animal cancer
Journal title
Pertanika Journal of Science and Technology ( JST)
Journal title
Pertanika Journal of Science and Technology ( JST)
Record number
2562540
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