Author/Authors :
Khozirah, S. Universiti Putra Malaysia - Institute of Bioscience - Laboratory of Natural Products, Malaysia , Noor Rain, A. Institute for Medical Research - Herbal Medicine Research Center, Kuala Lumpur , Siti Najila, M.J. Institute for Medical Research - Herbal Medicine Research Center, Malaysia , Imiyabir, Z. Forest Research Center, Malaysia , Madani, L. Forest Research Center, Malaysia , Rohaya, C. Institute for Medical Research - Herbal Medicine Research Center, Malaysia , Rosilawati, M. Institute for Medical Research - Herbal Medicine Research Center, Malaysia , Nuziah, H. Forest Research Institute of Malaysia (FRIM), Malaysia , Goh, S.H. Forest Research Institute of Malaysia (FRIM), Malaysia , Zakiah, I. Institute for Medical Research - Herbal Medicine Research Center, Malaysia
Abstract :
The antiplasmodial activity of the crude extracts of thirty plant species collected from Sabah was evaluated using chloroquine-sensitive strain (D10) and chloroquine-resistant strain (Gombak A) of Plasmodium falciparum. Significant activities were observed for the bark extract of Polyalthia insignis (IC50 3.89 and 11.89 mg/ml against Gombak A and D10, respectively), the leaf extracts of Kopsia dasyrachis (4.62 mg/ml against Gombak A) and Litsea elliptibacea (IC50 8.88 mg/ml against Gombak A), as well as the leaf and bark extracts of Neouvaria acuminatissima (IC50 6.90-10.08 and 0.69 mg/ml against Gombak A and D10, respectively), and the bark extract of Polyalthia microtus (IC50 9.0 and 12.12 mg/ml against Gombak A and D10, respectively)
Keywords :
Plasmodium falciparum , lactate dehydrogenase assay , Polyalthia insignis , Kopsia dasyrachis , Neouvaria acuminatissima , antimalarial
