Author/Authors :
Fallahian, M shahid beheshti university of medical sciences - Department of Obstetrics and Gynecology, تهران, ايران , Pouresmaeili, Farkhondeh shahid beheshti university of medical sciences - Reproduc-tive Health Research Center(IRHRC) - Department of Genetics, and Infertility, تهران, ايران , Azizi, F shahid beheshti university of medical sciences - Research Institute for Endo-crine Sciences - Endocrine Research Center, تهران, ايران , Zali, MR shahid beheshti university of medical sciences - Research Center for Gastrointestinal and Liver Disease - Taleghani Hospital, تهران, ايران , Samani, EM shahid beheshti university of medical sciences - Department of Obstetrics and Gynecology, تهران, ايران , Kharaziha, P shahid beheshti university of medical sciences - Taleghani Hospital - Research center for gastroenterology and liver diseases, تهران, ايران
Abstract :
remature ovarian failure (POF) is charac-terized by hypergonadotropic amenorr-hea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is pro-posed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.
Keywords :
Inhibin α , subunit gene , Premature ovarian failure , Mutation
