Author/Authors :
Annabestani, Zohreh tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Mohajeri-Tehrani, Mohammad Reza tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Tabatabaie–Malazy, Ozra tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Mohseni, Shahrzad tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Heshmat, Ramin tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Shahrzad, Mohammad Karim tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Larijani, Bagher tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران
Abstract :
Background: Transsphenoidal surgery (TSS) is the most effective treatment for acromegalic patients, and two major factors that have been suggested as useful predictors in assessing this therapy’s success are: tumor size and preoperative basal growth hormone (GH) levels.Objectives: The aim of this study was to illustrate the relationship between some predictor factors and transsphenoidal surgery (TSS) outcomes and its remission rate.Patients and Methods: A total of 20 patients underwent TSS by 4 neurosurgeons in 4 university hospitals in Tehran and were followed up for 1 year. An oral glucose tolerance test was performed at 1 week after surgery and then 3, 6, and 12 months after surgery. Moreover, Insulin Growth Factor- 1 (IGF-1) was measured at 6 and 12 months after surgery.Results: Initial remission was observed in 7 (35%) patients with a recurrence rate of 10%. The nonresponse rate was 55%. The analysis showed a significant relationship between IGF-1 and surgery outcome in the cured patients at 6 months after surgery (P = 0.005). No significant statistical relationship was found between tumor size and the TSS outcome (P = 0.696).Conclusions: Given the high failure and recurrence rates following TSS in Iran, it seems important to pay more attention to diagnosing the disease earlier and improving surgical methods.
