Title of article
Effect of Short-Term Administration of Glucagon on Gene Expression of the Insulin Receptor in Primary Cultured Calf Hepatocytes
Author/Authors
Zhang, Z. G. Northeast Agricultural University - College of Veterinary Medicine, China , Li, X. B. Jilin University - College of Animal Science and Veterinary Medicine, China , Liu, G. W. Jilin University - College of Animal Science and Veterinary Medicine, China , Chen, Y. Y. Northeast Agricultural University - College of Veterinary Medicine, China , Yu, M. L. Northeast Agricultural University - College of Veterinary Medicine, China , Wang, J. G. Jilin University - College of Animal Science and Veterinary Medicine, China , Wang, H. B. Northeast Agricultural University - College of Veterinary Medicine, China , Liu, L. Jilin University - College of Animal Science and Veterinary Medicine, China , Li, Y. F. Northeast Agricultural University - College of Veterinary Medicine, China , Gao, L. Northeast Agricultural University - College of Veterinary Medicine, China , Wang, Zhe Jilin University - College of Animal Science and Veterinary Medicine, China , Liu, L. Northeast Agricultural University - College of Veterinary Medicine, China , Zhu, X. L. Jilin University - College of Animal Science and Veterinary Medicine, China
From page
465
To page
467
Abstract
This study investigated whether increased glucagon levels, caused by the short-term administration of glucagon, lead to an increase in gene expression of the insulin receptor (InsR) in calf hepatocytes cultured in vitro. After 72 hrs of culturing, glucagon was added to calf hepatocytes at a five different concentrations of 0, 1, 10, 100 and 1000 nM. InsR mRNA expression was determined by internally controlled reverse transcriptase polymerase chain reaction. No changes in InsR mRNA expression (InsR/β-actin gray scale) were detected in hepatocytes treated with glucagon compared with the control group and there were no significant differences between the different concentrations. In conclusion, short-term administration of glucagon did not directly influence the gene expression of InsR in primary cultured calf hepatocytes.
Keywords
Calf hepatocyte , Insulin receptor , Gene expression , Glucagon
Journal title
Pakistan Veterinary Journal
Journal title
Pakistan Veterinary Journal
Record number
2562927
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