Author/Authors :
Perveen, Tahira University of Karachi - Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, Pakistan , Razi, Faiza University of Karachi - Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, Pakistan , Haider, Saida University of Karachi - Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, Pakistan , Qayyum, Hina University of Karachi - Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, Pakistan , Haleem, Darakhshaan J. University of Karachi - Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, Pakistan
Abstract :
Cod-liver oil is a rich source of omega 3 fatty acids and has been widely used as omega 3 fatty acids supplementation. Regarding omega-3 fatty acid beneficial effects in humans, this study was designed to investigate the effect of repeated administration of cod-liver oil on the locomotion and behaviors of rats, including depression, anxiety and the 5-Hydroxy tryptamine (5-HT) metabolism. After four weeks oral administration of cod-liver oil, open field test was used to measure the locomotor and exploratory activity. Elevated plus maze test was used to measure anxiety. Cod-liver oil significantly increased locomotion and produced anxiolytic effects in rats. Antidepressant effect of cod-liver oil was monitored by forced swim test (FST) in which struggling time of test animals was increased significantly. 5- HT turnover also increased significantly following the oral repeated administration of cod liver oil in test animals. The results suggest that cod-liver oil has antidepressant and anti-anxiety effects.
Keywords :
5 , HT , Antidepressant , Anxiolytic , Cod , liver oil , Rats
