Title of article :
Resveratrol Reduces Oxidative Stress and Improves Arsenic Efflux in Rats Exposed To Arsenic Trioxide
Author/Authors :
Zhang, Weiqian Northeast Agricultural University - College of Veterinary Medicine, China , Liu, Yan Inner Mongolia University for Nationalities - School of Life Sciences, China , Ge, Ming Northeast Agricultural University - College of Veterinary Medicine, China , Yao, Chunyu Inner Mongolia University for Nationalities - College of Animal Science and Technology, China , Xue, Jiangdong Inner Mongolia University for Nationalities - College of Animal Science and Technology, China , Zhang, Zhigang Northeast Agricultural University - College of Veterinary Medicine, China
Abstract :
The effects of resveratrol on arsenic trioxide-induced oxidative stress and arsenic efflux in spleen were determined in Wistar rats exposed to arsenic trioxide (As2O3). Wistar rats were segregated into four groups: control (0.9% normal saline), As2O3- treated (2 mg/kg for 7 days, i.p.), resveratrol+As2O3-treated, resveratrol-treated (5 mg/kg for 7 days, i.p.). Spleen was analyzed for lipid peroxidation, antioxidant enzyme activities, glutathione redox system and arsenic accumulation. Arsenic treatment showed significant increases in the malondialdehyde, reactive oxygen species and arsenic accumulation in spleen. Furthermore, arsenic treatment decreased significantly activity of superoxide dismutase and total glutathione/ oxidized glutathione ratio. However, treatment with resveratrol to arsenic-treated rats reduced oxidative stress and improved arsenic efflux. These findings may provide the potential strategy for arsenic-induced spleen toxicity and As2O3 as a single agent causing toxic effects.
Keywords :
Arsenic efflux , Arsenic trioxide , Oxidative stress , Resveratrol
Journal title :
Pakistan Veterinary Journal
Journal title :
Pakistan Veterinary Journal
