Title of article :
Kinetin Protects D-Galactose-Induced Aging Rats from Splenic Oxidative Damage
Author/Authors :
Li, Mengyun Northwest A F University - College of Veterinary Medicine, China , Li, Mengyun Henan University of Science and Technology - College of Animal Science and Technology, China , Ouyang, Wuqing Northwest A F University - College of Veterinary Medicine, China , Wu, Xiaoli Northwest A F University - College of Veterinary Medicine, China , Zheng, Yin Northwest A F University - College of Veterinary Medicine, China , Gao, Rui Northwest A F University - College of Veterinary Medicine, China , Ouyang, Xu Northwest A F University - College of Veterinary Medicine, China , An, Lei Northwest A F University - College of Veterinary Medicine, China
Abstract :
The molecular mechanisms specifying anti-oxidative and anti-aging action of kinetin (Kn) on the splenic oxidative damage of aging rats are poorly understood. Here, the Sprague Dawley (SD) rats (Rattus norregicus) aging model was proposed by napes subcutaneous injection of D-galactose, and anti-aging group were subsequently dealt with doses of 5, 10, 20 mg/kg·BW of Kn. Superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-PX), catalase (CAT), lipid peroxide (LPO), spleen indexes and histopathology were evaluated. Our results showed that Kinetin significantly decreased the MDA and LPO activity, while spleen indexes, SOD, GSH-PX and CAT were higher than aging model group; histopathological studies for spleen confirmed the rescue from the aging rats. These results demonstrate that kinetin recovers the splenic cell structure and could effectively protect the spleen cells from oxidative damage and aging.
Keywords :
Aging , D , galactose , Kinetin , Oxidative damage
Journal title :
Pakistan Veterinary Journal
Journal title :
Pakistan Veterinary Journal
