HEPATOPROTECTIVE ACTIVITY OF Iphiona grantioides AND Pluchea arguta FOR ACETAMINOPHEN INDUCED TOXICITY IN RABBITS

The present study was aimed to explore the hepatoprotective role of Iphiona grantioides (IG) and Pluchea arguta subsp. glabra (PA) ethanolic extract (EE) in acetaminophen induced liver toxicity in rabbits. The experiment was conducted during April, 2011. Ethanolic extracts of Iphion agrantioides (IG) and Pluchea arguta subsp. glabra (PA) at three different dosages, administered orally for three days, significantly reduced the serum enzymes; Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), and serum bilirubin. In this study, silymarin was used as a standard hepatoprotective drug. The results of this study showed that Iphion agrantioides (IG) and Pluchea arguta subsp. glabra (PA) ethanolic extract (EE) had hepatoprotective potential against acetaminophen induced liver toxicity in rabbits. The biochemical observations were supported with histopathological examination of rabbit liver sections. These findings exposed that the hepatoprotective activity of the ethanolic extracts of Iphiona grantioides (Bioss.) and Pluchea arguta subsp. glabra might be due to the presence of unique chemical constituents such as flavonoids, sesqueterpene, triterpenes and sterols.