Author/Authors :
Ding, Chuan Hun Universiti Kebangsaan Malaysia - Medical Centre - Department of Medical Microbiology Immunology, Malaysia , Tzar, Mohd Nizam Universiti Kebangsaan Malaysia - Medical Centre - Department of Medical Microbiology Immunology, Malaysia , Rahman, Md Mostafizur Universiti Kebangsaan Malaysia - Medical Centre - Department of Medical Microbiology Immunology, Malaysia , Muttaqillah, Najihan Abdul Samat Universiti Kebangsaan Malaysia - Medical Centre - Department of Medical Microbiology Immunology, Malaysia , Redzuan, Shazatul Reza Mohd Universiti Kebangsaan Malaysia - Medical Centre - Department of Medicine, Malaysia , Periyasamy, Petrick Universiti Kebangsaan Malaysia - Medical Centre - Department of Medicine, Malaysia
Abstract :
Fungaemia due to Paecilomyces lilacinus is generally not considered in AIDS patients because this condition is not categorised as an AIDS-indicator illness. We report a case of a 25-year-old lady who presented to our hospital with Guillain-Barré Syndrome, with the subsequent development of refractory fungaemia, multi-organ failure and disseminated intravascular coagulopathy. Amphotericin B was given as empirical antifungal therapy. HIV screening was reactive and Paecilomyces lilacinus was isolated from her blood. The fungaemia did not resolve after one week of amphotericin B treatment. The addition of itraconazole was also unsuccessful in clearing the fungaemia. Accurate mycological diagnosis is important in the care of AIDS patients with fungaemia because of the risk of treatment failure with empirical therapy.
Keywords :
AIDS , Paecilomyces lilacinus , Fungaemia , Amphotericin B , Voriconazole
