Author/Authors :
Shang, Yu-Xiu Ningxia Medical University - Department of Public Health, China , Shang, Yu-Xiu Xi’an Jiaotong University - School of Medicine - Department of Epidemiology and Biostatistics, China , Ding, Wen-Qing Ningxia Medical University - Department of Public Health, China , Qiu, Hong-Yan Ningxia Medical University - Department of Public Health, China , Zhu, Feng-Ping Zhongwei City People’s Hospital - Department of Cardiology, China , Yan, Shu-Zhen Zhongwei City People’s Hospital - Department of Cardiology, China , Wang, Xue-Liang Xi’an Jiaotong University - School of Medicine - Department of Epidemiology and Biostatistics, China
Abstract :
Objective: The aim of this study was to examine the associations between depression and inflammatory markers in patients admitted to the hospital for myocardial infarction. Methods: Inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)- 1β, IL-6, and tumor necrosis factor-α (TNF-α) were assessed in a group of 75 depressed participants (score of ≥ 12) and compared to a control group of 75 nondepressed participants (score 12), all who had been admitted to the hospital for myocardial infarction. The presence of depressive symptoms was assessed using the Beck Depressive Symptoms Inventory II Scale (BDI-II). Results: Depressed myocardial infarction participants had significantly greater levels of TNF-α (t = 2.070, P 0.05) compared with control myocardial infarction participants. The BDI-II score was positively correlated with TNF-α levels (r = 0.222, P 0.05). Conclusions: These results indicate that the presence of depressive symptoms is positively associated with TNF-α levels among patients who have suffered from myocardial infarction.
