Pregnancy Outcomes Among Hospitalized Patients Infected With 2009H1N1 Influenza Virus in Qom, Iran, in Oct-Nov. 2009

Background: Pandemic H1N1 influenza A 2009 (H1N1/09) virus has been identified as a leading cause of febrile respiratory diseases worldwide,and pregnant women constitute a high risk group. Objectives: To determine the clinical characteristics and outcomes of pregnant women with H1N1 influenza A hospitalized in university hospitals of Qom city in Iran. Patients and Methods: This descriptive retrospective study was conducted using existed data related to October and November 2009. Allpregnant women with influenza manifestations were admitted to the hospitals to undergo nasopharyngeal culture. H1N1 virus was confirmedin 11 cases. Data including demographic characteristics, clinical manifestations, laboratory test results, and pregnancy complications was extracted from medical records, and analyzed by descriptive statistics. Results: The mean age of the women was 28.1 ± 4.7 years with a mean gestational age of 28.7 ± 10.9 weeks. The most common clinical manifestations included coughing (100%), fever (87.5%), and dyspnea (75%). The most common abnormal test was anemia (88%). Pregnancy complications included preterm delivery (36.3%), low birth weight (18%), oligohydramnios (9%), gestational diabetes (9%), and fetal distress(9%). Also one (12.5%) wound dehiscence happened. Conclusions: vaccination seems to be necessary to prevent this potentially fatal infectious disease. Furthermore, timely prescription ofantiviral medications is recommended to decrease the risk of severe complications.