Antidibetic, antihyperlipidemic and antioxidative effects of Aegle marmelos and silymarin on alloxan induced diabetes in mice

This project was designed for the evaluation of the antidibetic, antihyperlipiemic and antioxidative effect of Aegle marmelose (L.) Correa ex Roxb., and silymarin on alloxan induced diabetes in mice. A total of 15 mice were used which were divided into five groups as A, B, C, D and E. Group A was treated with normal chick’s diet. Alloxan were given at 150 mg kg^-1 body weight through abdominal region, to all groups with the exception of control. Group B was diabetic mice, group C was treated with silymarin (200 mg kg^-1) of body weight, group D was treated with A marmelose (180 mg kg^-1) of body weight and Group E treated with silymarin (200 mg kg^-1) and A. marmelose (180 mg kg^-1) of body weight. Blood samples were taken from the coccygeal vein of the mice for the estimation of glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, malondialdehyde, oxidative stress marker, glutathione, superoxide dismutase and catalase activity. Results showed that A. marmelos and silymarin reduced the oxidative stress and increased the level of glutathione, superoxide dismutase, catalase and thiobarbituric acid reactive substances. It was concluded from the present study that A. marmelos and silymarin can reduce the diabetes in mice.