Author/Authors :
Johari Daha, F. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران , Shafiei, M. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران , Sheibani, Sh. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران , Tavakoli, Y.H. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران , Mazidi, M. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران , Mirfalah, M.H. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران , Babaei, M. H. Atomic Energy Organization of Iran - Nuclear Science Research School, Nuclear Science and Technology Research Institute - Radioisotope Department, ايران
Abstract :
Background: Owing to its favourable decay characteristics 177Lu [T1/2= 6.71 d, EBeta(max)= 497 keV] is an attractive radionuclide for various therapeutic applications. Ethylene diamine tatrame- thylene phosphonate (EDTMP) is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. Materials and Methods: Enriched 176Lu2O3 was dissolved in 0.1 N HCl and evaporated several times and 176LuCl3 target was irradiated at 2.6 ~1013 n.Cm- 2.S-1 thermal neutron flux for 14 days.177LuCl3 was dissolved in 1N HCl. EDTMP was dissolved in double distilled water at pH=7.5-8.5 and freeze-dried kits was radiolabeled with 177LuCl3. Distribution studies were done in healthy mice. Results: The yield of 177Lu was (~220 TBq/g; 6000 Ci/g), the radionuclidic purity was ~99%.The radiolabeling yield of EDTMP kits at 37 degreeC after 30 min and 4 hours was 98+-0.5% and after 72 hours was 90+-2.1%, the in vitro stability in human serum at 37degreeC up to 72 hours post radio- labeling was 85+-1.8%.The biodistribution studies of 177Lu-EDTMP and 177LuCl3 in normal mice showed skeleton uptake and low soft-tissue concentration. Conclusion: In this study, we produce ~220 TBq/g (6000 Ci/g) of 177Lu by neutron activation of 176Lu in the Tehran Research Reactor. Our results showed 177Lu-EDTMP as a bone-seeking radiopharmaceutical. Due to its suitable nuclear characteristics 177Lu appears to be worthwhile for palliative therapy of bone metastasis.
Keywords :
EDTMP , Bone , seeking radiopharmaceuticals , 177Lu.
