POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE IS ASSOCIATED WITH EPSTEINBARR VIRUS

The post-transplant lymphoproliferative disorder (PTLD) is defined in large part by their occurrence following organ transplantation and by their histopathological appearance. The vast majority is associated with Epstein -Barr virus (EBV) infection. Their recognition is important because underdiagnosis as a not otherwise specified reactive process may lead to continued immunosuppression and progression of disease and overdiagnosis as a conventional lymphoma may lead to inappropriate and potentially fatal chemotherapy. In this article pathogenesis, clinical cause, and therapy of PTLD have been presented and the role of EBV described.