Author/Authors :
SOLIMAN, KAWTHER M. National Research Center - Department of Medicinal Chemistry, Egypt , SOLIMAN, KAWTHER M. Cairo University - Faculty of Medicine - Department of Medical Biochemistry, Egypt , HAMED, MANAL A. Cairo University - Faculty of Medicine - Department of Medical Biochemistry, Egypt , HAMED, MANAL A. National Research Center - Department of Medicinal Chemistry, Egypt , ALI, SANAA A. Cairo University - Faculty of Medicine - Department of Medical Biochemistry, Egypt , ALI, SANAA A. National Research Center - Department of Medicinal Chemistry, Egypt
Abstract :
SUMMARY: The aim of the present study is to investigate the effect of ethanol and the action of carnosine treatment on certain liver parameters; enzymes, total proteins and glycogen in rats. These enzymes including Krebs cycle enzyme: succinate dehydrogenase (SDH); glycolytic enzymes: lactate dehydrogenase (LDH) and its isoenzymes; glycogenolytic metabolic machineries: glycogen phosphorylase, G-6-Pase and glycogen; hydrolytic enzymes: acid phosphatase (AP) and alkaline phosphatase (ALP); amino acid metabolic enzymes: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and nucleic acid catabolic enzyme: 5`-nucleoti- dase. The chronic ethanol-intoxicated rats showed a marked disturbance in all the parameters measured, indi- cating the toxic effect of ethanol by inducing oxidative stress on liver tissue. Administration of carnosine ameliorated the toxic effects of ethanol.
Keywords :
Ethanol toxicity , Carnosine , Enzymes , Glycogen
