Mortality After Acute Myocardial Infarction: Significance of Cardiovascular Diabetic Autonomic Neuropathy (CDAN)

The aim of this study was to compare intrahospital and long-term mortalitiesafter more than 10 years of the follow up after the first acute myocardial infarction(AMI) with patients with and without CDAN and without diabetesmellitus (DM). Methods: The study was based on 76 (43 men and 33 women) withDM type 2, CDAN was detected in 51 patients, and 374 (295 men and 79 women)without DM consecutively hospitalized with the first-ever AMI from January 1998.to December 2000. in Clinical Center of Montenegro Podgorica. Patients were followeduntil December 31. 2011. CDAN was searched for by standardized five testsevaluating heart rate and blood pressure variations. Results: Intrahospital mortalitywas presented in 10. 53 % diabetic patients and 5. 61 % nondiabetic patients, thisdifference is significant (p=0.048). Long-term mortality was presented at 24 (82.75%) patients with CDAN and 5 (17. 25%) patients without CDAN (p=0.029). Longterm mortality rate was significantly higher in diabetic patients 29 (42. 64 %) than innondiabetic patients 102 (30. 72 %) (p=0.012). Conclusion: Intrahospital mortalitywas significantly higher in diabetic than in nondiabetic patients. Identically the mortalityafter more than 10 years of the follow up after the first AMI was significantlyhigher in diabetic with, than in diabetic patients without CDAN, as in diabetic thanin nondiabetic patients.