A Clinical Sign in Pediatric Sclerosis, Farhad’s Sign

The scleroderma group of diseases is characterized by the presence of hard skin. The pathogenesis of scleroderma include excessive production of collagen and extracellular matrix by fibroblasts, not only in the skin but also in vital organs and around blood vessels with endothelial cell injury. Systemic Sclerosis (SSc) usually constitutes less than 1% of most pediatric rheumatology clinic populations. Females are affected much more commonly than males.