Author/Authors :
Akhlaq, Muhammad Gomal University - Faculty of Pharmacy, Gomal Center of Biochemistry Biotechnology, Institute of Chemical Sciences, Pakistan , Hussain, Abid Poonch University - Department of Pharmacy, Pakistan , Bakhsh, Satar Gomal University - Faculty of Pharmacy, Gomal Center of Biochemistry Biotechnology, Institute of Chemical Sciences, Pakistan , Abdul Shakoor Gomal University - Faculty of Pharmacy, Gomal Center of Biochemistry Biotechnology, Institute of Chemical Sciences, Pakistan , Khan, Muzammil Ahmad Gomal University - Faculty of Pharmacy, Gomal Center of Biochemistry Biotechnology, Institute of Chemical Sciences, Pakistan , Iqbal, Shahid Kohat University of Sciences Technology - Department of Chemistry, Pakistan , Kiran, Shumaila Gomal University - Faculty of Pharmacy, Gomal Center of Biochemistry Biotechnology, Institute of Chemical Sciences, Pakistan
Abstract :
The transdermal route is considered an efficacious and innovative route in drug delivery and is attaining the consideration of pharmaceutical scientists for the last two dacades. For a successful transdermal drug delivery system (TDDS), a drug must infiltrate through the skin to underlying tissues and circulation without any drug accumulation in skin layers. The passage of therapeutic quantities of drug substances through skin into the general circulation for their systemic effects is facilitated by TDDS. Major problem that TDDS faces is dermal barrier. Attempts have been made to overcome this barrier to facilitate the passage of drug through skin for its therapeutic effect. This review aims to present the analysis of published research work to investigate the permeation of various drugs through skin port using different permeation enhancers
