Author/Authors :
Geng, Yansheng Hebei University - Health Science Center, China , Zhang, Hongxin Hebei University - Health Science Center, China , Huang, Weijin National Institutes for Food and Drug Control - Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, China , Harrison, Tim J University College London Medical School - Division of Medicine, UK , Geng, Kunjing Baoding Hospital for Infectious Disease, China , Li, Zhuo Capital University of Medical Sciences - Affiliate Beijing You’an Hospital, Hepatitis Institute of Beijing Municipal Health Bureau, China , Wang, Youchun National Institutes for Food and Drug Control - Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, China
Abstract :
Introduction: In general, the hepatitis E virus (HEV) causes acute, self-limiting hepatitis. Prolonged and chronic infections caused by HEV genotype 3 have been found in some immunosuppressed patients in developed countries. Case Presentation: Here we report a Chinese boy with acute lymphoblastic leukemia, who developed hepatitis E during a period of intensive chemotherapy. Twenty months after the initial infection, HEV viremia was reappeared in the patient, with detectable anti-HEV IgM and IgG and modestly elevated serum transaminases. Sequence analysis of the viral RNAs revealed the reactivation of the HEV genotype 4d strain, indicating viral persistence in the patient. Conclusions: To our knowledge, this is the first chronic case confirmed by the prolonged presence of HEV RNA in china. It is also the first reported persistent hepatitis E infection caused by HEV genotype 4.
Keywords :
Hepatitis E virus , Precursor Cell Lymphoblastic Leukemia , Lymphoma , Chronic Hepatitis , Persistent Infection
