Author/Authors :
lajimi, Abdolreza Ardeshiry Stem Cell Technology Research Center - Stem Cell Biology Department, ايران , Farshdousti Hagh, Majid tabriz university of medical sciences - Faculty of Medicine - Division of Laboratory Hematology and Blood Banking, ايران , Saki, Najmaldin ahvaz jundishapur university of medical sciences - Research Center of Thalassemia Hemoglobinopathy, اهواز, ايران , Mortaz, Esmaeil Utrecht University - Faculty of Sciences, Utrecht Institute for Pharmaceutical Sciences - Division of Pharmacology and Pathophysiology, Netherlands , Soleimani, Masoud tarbiat modares university - Faculty of Medical Science - Hematology Department, تهران, ايران , Rahim, Fakher ahvaz jundishapur university of medical sciences - Toxicology Research Center, اهواز, ايران
Abstract :
Multiple Sclerosis is an inflammatory disease of the central nervous system in which T cells experience a second phase of activation, which ultimately leads to axonal demyelination and neurological disability. The recent advances in stem cell therapies may serve as potential treatments for neurological disorders. There are broad types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unprecedented hope in treating many debilitating diseases. In this paper we will review the substantial literature regarding experimental and clinical use of these stem cells and possible mechanisms in the treatment of MS. These results may pave the road for the utilization of stem cells for the treatment of MS.
Keywords :
Multiple sclerosis , Stem cells therapy , Human embryonic stem cells , Hematopoietic stem cells , Mesenchymal stem cells , Neural stem cells
