The Effect of Primary Bolus Dose of Pancuronium versus Cisatracurium without Maintenance Dose on Extubation Time in Adult Coronary Artery Bypass Grafting

Background- Given the importance of the effect of muscle relaxants on the extubation time in coronary artery bypass grafting (CABG) patients, we sought to assess the difference in time to extubation and intensive care unit (ICU) length of stay between the primary bolus doses of Pancuronium and Cisatracurium without using the maintenance dose of them during surgery. Methods- This double blind clinical trial divided 110 patients into two equal groups receiving either Cisatracurium or Pancuronium. The patients surgical and cardiopulmonary bypass variables were evaluated, and the extubation time and ICU length of stay were compared between the two groups. Results- There was 110 difference between the two groups regarding the depth of anesthesia, train-of-four (TOF) scores at the beginning of anesthesia, and the surgical and cardiopulmonary bypass variables. However, the Cisatracurium patients were extubated earlier and had a shorter ICU length of stay than the Pancuronium patients. Conclusion- An appropriate depth of anesthesia facilitates the administration of the induction dose of Cisatracurium, which confers earlier extubation and shorter ICU length of stay by comparison with Pancuronium