Author/Authors :
Ahmadpoor, Pedram shahid beheshti university of medical sciences - Shahid Labbafinejad Medicalcenter - Department of Medicine,Division of Nephrology, تهران, ايران , Pour-Reza-Gholi, Fatemeh shahid beheshti university of medical sciences - Shahid Labbafinejad Medical Center - Departments of Nephrology and Pathology, تهران, ايران , Nafar, Mohsen shahid beheshti university of medical sciences - Shahid Labbafinejad Medical Center - Department of Medicine,Division of Nephrology, تهران, ايران , Parvin, Mahmood shahid beheshti university of medical sciences - Shahid Labbafinejad Medical Center - Department of Pathology, تهران, ايران , Samadian, Fariba shahid beheshti university of medical sciences - Shahid Labbafinejad Medical Center - Division of Nephrology, Department of Medicine, تهران, ايران , Samavat, Shiva shahid beheshti university of medical sciences - Shaheed Labbafinejad Medical Center - Department of Nephrology, تهران, ايران , Amirkhanloo, Saeed shahid beheshti university of medical sciences - Shahid Labbafinejad Medical Center - Departments of Nephrology and Pathology, تهران, ايران
Abstract :
A 67-year-old female kidney transplant recipient
with nephrotic-range proteinuria was admitted for
kidney biopsy. She had undergone living unrelated
kidney transplantation in 1999 due to kidney failure
of unknown cause after being on hemodialysis for
8 months. Her donor was a 23-year-old female who
was homozygous for human leukocyte antigen
(HLA) B5, DR 52, DQ 1, and CW 4. The patient’s
HLA type was A2, B5, B35, DR11, DR52, DQ1,
and CW4. Immunosuppressive therapy consisted
of cyclosporine, azathioprine, and steroids. Two
months after transplantation, she had developed
an episode of acute allograft dysfunction due to
calcineurin toxicity which had responded to dose
reduction. Her high blood pressure had been
treated with atenolol, to which enalapril had been
added 2 years later. Six years after transplantation,
azathioprine had been converted to mycophenolate
mofetil. Her clinical course was uneventful until
a year after conversion when she developed
progressive proteinuria without hematuria or
worsening of graft function.
Keywords :
Nephroquiz 6 , Kidney Transplant Recipient , Proteinuria , Nephrotic-Range
