Author/Authors :
Mohammadpour, Amir Hooshang mashhad university of medical sciences - Pharmaceutical Research Center School of Pharmac - Department of Pharmacodinamy Toxicology, مشهد, ايران , Nazemian, Fatemeh mashhad university of medical sciences - Imam-Reza Hospital - Division of Nephrology, Department of Internal Medicine, مشهد, ايران , Moallem, Adel mashhad university of medical sciences - School of Pharmacy - Department of Pharmacodynamics and Toxicology, مشهد, ايران , Moallem, Adel mashhad university of medical sciences - Pharmaceutical Sciences Research Center, مشهد, ايران , Moallem, Adel mashhad university of medical sciences - Medical Toxicology Research Center, مشهد, ايران , Alamdaran, Ali mashhad university of medical sciences - Imam Reza Hospital - Department of Radiology, مشهد, ايران , Asad-Abadi, Elham mashhad university of medical sciences - Pharmaceutical Sciences Research Center, مشهد, ايران , Shamsara, Jamal mashhad university of medical sciences - Pharmaceutical Sciences Research Center, مشهد, ايران
Abstract :
Introduction. Cardiovascular disease is a major factor in the deterioration of the health and the death of hemodialysis patients. Previous studies have mainly shown a decreased level of heat shock protein 27 (HSP27) in patients with cardiovascular disease. We conducted this study to investigate whether HSP27 correlates with common carotid intima-media thickness (CCIMT) and if it has a potential to be a biomarker for cardiovascular disease. Materials and Methods. In this cross-sectional study, the correlation between HSP27 serum concentration and CCIMT was investigated in 42 hemodialysis patients. An enzyme-linked immunosorbent assay method was used to measure HSP27 level in the plasma of the patients, and a high-resolution B-mode ultrasonography was applied to measure CCIMT.Results. There was an inverse significant correlation between serum concentration of HSP27 and CCIMT only in patients that had hypertension as their only cardiovascular risk factor (r = - 0.61, P = .02).Conclusions. According to our results and the fact that HSP27 has been shown to be expressed in atherosclerotic plaques of both experimental animals and humans, we suggest that circulatory HSP27 concentration has a potential of being used as a marker for cardiovascular events.
