Author/Authors :
Afrashi, Mehran Department of Textile Engineering - Isfahan University of Technology, Isfahan 84156-83111, Iran , Semnani, Dariush Department of Textile Engineering - Isfahan University of Technology, Isfahan 84156-83111, Iran , Alihosseini, Farzaneh Department of Textile Engineering - Isfahan University of Technology, Isfahan 84156-83111, Iran , Dehghan, Parvin Department of Parasitology and Mycology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Maheronnaghsh, Mehrnoush Department of Parasitology and Mycology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
In this research, the anti-fungal effect of fluconazole-loaded polyvinyl alcohol (PVA) nano-fibers was compared with that of drug-loaded fabric (DLF) to be used in medical textiles and fibrous pads as a local drug delivery system. The drug-loaded nano-fibers (DLNs) were coated on the fabric surface using the electro-spinning process. The DLF was then prepared by means of the pad-dry method. The characterization of the samples was carried out by SEM, FTIR, and XRD tests. UV-V is spectrophotometry was also used to measure the drug release rate. The anti-fungal effect was studied by the disk diffusion method. The drug release test showed about 75% fluconazole release in 90 min and the disc diffusion test indicated that the DLF has more effect than the DLN due to the fast drug release.
Keywords :
nano-fibers , candida albicans , vulvovaginal candidiasis , fluconazole , drug delivery system
