Comparison of Boric Acid with Clotrimazole in the Treatment of Recurrent or Resistant Vulvovaginitis Caused by Non-Albicans Species of Candida

Background: Vulvovaginal candidias is is one of the most common infections in gynecologic filed, and non-albicans Candida specie s are emerging causative microorganisms. This specie s shows resistance to routine treatments. One of the suggested treatment s is admini stration of vaginal suppositories of boric acid. The aim of the present study was to compare boric acid with clotrimazole in the treatment of recurrent or resistant vulvovaginitis. Methods: In a double-blind , randomized clinical trial, 90 nonpregnant women were enrolled . The patients were divided into two groups to receive ; boric acid (300 mg twice a day for 2 weeks) or clotrimazole ( 100 mg once a day for 2 weeks) intravaginall y. Treatment responses were monitored by laboratory and clinical data. Results: Treatment response s were significantly different in laboratory resu Its for boric acid and clotrimazo Ie groups (86.7% v 60%, P= 0.004). Clinical respons es (improved signs and symptoms) showed no significant differences (8.2. v 6.5, P= 0.02). Drug side effe cts were not different in boric acid and clotrim azole groups (13.3% v 11.1%, P= 0.75). Conclusion: Intra-vaginal administration of boric acid is more effective than clotrimazole in vaginal candidias is caused by non-albi cans species.