Author/Authors :
Esfahanian, Vahid islamic azad university - Dental faculty - Department of Periodontology, ايران , Farhad, Shirin Zahra islamic azad university - Dental faculty - Department of Periodontology, ايران , Sadighi Shamami, Mehrnaz tabriz university of medical sciences - Faculty of Dentistry - Department of Periodontics, ايران , Mesripour, Manoochehr islamic azad university - Department of Biochemistry, ايران , Ghafari, Mohamadreza islamic azad university - Department of Biochemistry, ايران , Mafi, Morvarid Khorasgan Islamic Azad Dental School (Isfahan) - Department of Periodontics, ايران , Kouchakian, Farnaz Islamic Azad Dental School (Isfahan), Khorasgan Branch - Department of Periodontics, Young Researchers Club, ايران
Abstract :
Background and aims. Despite available evidence for the role of herpes viruses in destructive periodontal diseases, no cause-and-effect relationship has been found to date. This study compared the titer of immunoglobulin G (IgG), immunoglobulin M (IgM) against human cytomegalovirus (HCMV) in gingival crevicular fluid between individuals with periodontitis and with healthy periodontium. Materials and methods. Thirty samples of gingival crevicular fluid (ten from infected sites and ten from non-infected sites from ten individuals with periodontitis and ten from ten individuals with healthy periodontium) were provided. The titer of IgG and IgM were evaluated. Data was analyzed by one-way ANOVA, Kruskal-Wallis test, t-test, Duncen’s test and Pearson’s correlation coefficient. Results. There were no statistically significant differences in the means of IgM titers of the three groups under study (P 0.05), but there were significant differences in IgG titers between the three groups (P 0.001). Conclusion. Within the limits of the present study, it can be concluded that IgG titers against the human cytomegalovirus can increase in patients with periodontal diseases but the IgM titers do not show a significant increase in these individuals.
Keywords :
Chronic periodontitis , cytomegalovirus , gingival crevicular fluid , immunoglobulin G , immunoglobulin M.
