Title of article :
A Review of Tissue‐Engineered Cartilage Utilizing Fibrin and Its Composite
Author/Authors :
Pourentezari ، Majid Department of Anatomy and Molecular Biology - Shahid Sadoughi University of Medical Sciences , Anvari ، Morteza Department of Anatomy and Molecular Biology - Shahid Sadoughi University of Medical Sciences , Yadegari ، Maryam Department of Anatomy and Molecular Biology - Shahid Sadoughi University of Medical Sciences , Abbasi ، Abolghasem Department of Anatomy and Molecular Biology - Shahid Sadoughi University of Medical Sciences , Dortaj ، Hengameh Department of Tissue Engineering and Applied Cell Science - Shiraz University of Applied Medical Science and Technologies
Abstract :
Suitable alternatives are made for damaged or diseased organs and tissues in tissue engineering by combining cellular and molecular biology with materials and mechanical engineering. Fibrin is a critical blood component responsible for homeostasis, used extensively as a biopolymer scaffold in tissue engineering. This study summarizes the latest developments in organ and tissue regeneration using fibrin as a scaffold material. The combination of active peptides and growth factors through a heparinbound delivery system improves fibrin function as a scaffold. Besides, the development of fibrin precursors as recombinant proteins solves multiple or single donor fibrin adhesives. Its composite allows biomolecules to be combined with fibrin and can significantly enhance fibrin efficacy in cartilage tissue engineering applications.
Keywords :
Fibrin , Fibrin Composite , Fibrinogen , Cartilage , Scaffold
Journal title :
International Journal of Medical Laboratory
Journal title :
International Journal of Medical Laboratory
