Author/Authors :
Aydi, Z. Habib Thameur Hospital - Internal Medicine Department, Tunisia , Ben Dhaou, B. Habib Thameur Hospital - Internal Medicine Department, Tunisia , Ben Brahim, E. Habib Thameur Hospital - Anatomopathology Department, Tunisia , Baili, L. Habib Thameur Hospital - Internal Medicine Department, Tunisia , Boussema, F. Habib Thameur Hospital - Internal Medicine Department, Tunisia , Ketari, S. Habib Thameur Hospital - Internal Medicine Department, Tunisia , Cherif, O. Habib Thameur Hospital - Internal Medicine Department, Tunisia , Debbiche, A. Habib Thameur Hospital - Anatomopathology Department, Tunisia , Rokbani, L. Habib Thameur Hospital - Internal Medicine Department, Tunisia
Abstract :
Primary cutaneous aggressive CD8+ T-cell lymphoma is an extremely rare entity with distinct clinicopathological features. We report a case of a 28-year-old man that clinically presented with an ulcerated nodule on his trunk and extremities. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. Immunohistochemically, the tumor cells were positive for CD3 and CD8 but negative for CD4, CD20, CD30 and CD56. Granzyme B was positif. He received UVB therapy subsequently associated to interferon with an important regression of the nodules.
Keywords :
CD8+ T , cell lymphoma , Interferon , Ulcerated skin nodule
