Author/Authors :
Özgüven, Salih Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Kesim, Selin Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Öksüzoğlu, Kevser Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Şen, Feyza Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Öneş, Tunç Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , İnanır, Sabahat Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Turoğlu, Halil Turgut Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Erdil, Tanju Yusuf Marmara University Pendik Training and Research Hospital - Clinic of Nuclear Medicine - İstanbul, Turkey , Yanartaş, Mehmed University of Health Sciences Turkey - Kartal Koşuyolu Training and Research Hospital - Clinic of Cardiovascular Surgery - İstanbul, Turkey , Taş, Serpil University of Health Sciences Turkey - Kartal Koşuyolu Training and Research Hospital - Clinic of Cardiovascular Surgery - İstanbul, Turkey , Mutlu, Bülent Marmara University Pendik Training and Research Hospital - Clinic of Cardiology - İstanbul, Turkey , Yıldızeli, Bedrettin Marmara University Pendik Training and Research Hospital - Clinic of Thoracic Surgery - İstanbul, Turkey
Abstract :
Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension with persistent pulmonary vascular obstruction and exercise intolerance, which may benefit from pulmonary endarterectomy (PEA). Ventilation/perfusion (V/Q) scan is the preferred screening test of CTEPH, which can be used to assess the anatomical extent of the disease. This study aimed to analyze the correlation between the extent of mismatched Q defects in V/Q single photon emission computed tomography/computed tomography (SPECT/CT) with preoperative clinical and hemodynamic parameters in patients with CTEPH.Methods: A total of 102 patients with CTEPH prior to PEA having V/Q SPECT/CT scans were retrospectively reviewed. Age, gender, New York Heart Association classification, intraoperative right-sided heart catheterization (mPAP and PVR), and 6-minute walk test (6MWT) findings were obtained from clinical records of patients.Results: Linear regression analysis showed a significant but weak correlation between the preoperative mPAP and PVR with the extent of mismatched Q defects in V/Q SPECT/CT (rs=0.09474 with p=0.0016 and rs=0.045 with p=0.045, respectively). No significant correlation was found between 6MWT and extent of mismatched Q defects in V/Q SPECT/CT (p>0.05).Conclusion: A quantitative assessment of Q defects on V/Q SPECT/CT might provide information about hemodynamic parameters in patients with CTEPH.
Keywords :
6-minute walk distance , pulmonary vascular resistance , Chronic thromboembolic pulmonary hypertension , mean pulmonary arterial pressure , ventilation/perfusion scintigraphy
