COMPARISON OF FEMALE REPRODUCTIVE ORGANS MORPHOLOGY BETWEEN FERTILE AND INFERTILE WOMEN WITH POLYCYSTIC OVARIES

Objective: To compare the morphology of pelvic reproductive organs between fertile and infertile women with polycystic ovaries.Methodology: This cross sectional comparative study was performed at Rahat Hospital, Karsaz Karachi from January 2008 to December 2008. In which 100 women diagnosed with polycystic ovaries identified by ultrasound were inducted for the study; 50 were fertile and 50 were infertile (20-40 years). Transabdominal scan (TAS) was performed to rule out abnormalities other than PCO. Ovarian volume (OV) in cm3, follicle count (FC) and size (FS) in mm, uterine area (UA) in cm2, endometrial thickness (Endo) in mm were measured and noted by transvaginal scanning (TVS) ; Basal Metabolic Rate (BMI) was calculated and correlated with endometrial thickness. Unpaired t-test and Pearson correlation were used for analysis.Result: In the total fertile and infertile women with PCO the following result was obtained OV-TAS 7.33±3.17 vs. 10.87±2.49(0.001), OV-TVS 8.79±2.19 vs. 12.44±2.36(0.001), FC 14.41±2.18 vs. 14.75±2.80 (0.245), FS 3.26±0.22 vs. 8.99±0.45 (0.001), BMI 25.6±4.7vs. 27.6±5.7(0.04), UA 86.9±25.7 vs. 117.2±29.0(0.001) and Endo 4.5±1.4 vs. 5.8±1.9(0.052). BMI and endometrial thickness showed a positive correlation with r value of 0.06(0.05) in the infertile women and a negative correlation with r value of - 0.40(0.05) in fertile women.Conclusion: The OV, FS, BMI, UA and Endo show a significant increase in the infertile women who are suffering from PCO. However the FC showed no significant difference between the two groups. The BMI and endometrial thickness has shown a positive correlation with infertility