Author/Authors :
Reisi, Parham isfahan university of medical sciences - School of Medicine - Department of Physiology, اصفهان, ايران , Alaei, Hojjatallah isfahan university of medical sciences - School of Medicine - Department of Physiology, اصفهان, ايران , Babri, Shirin tabriz university of medical sciences - Neurosciences Research Center, تبريز, ايران , Sharifi, Mohammad Reza isfahan university of medical sciences - School of Medicine - Department of Physiology, اصفهان, ايران , Mohaddes, Gisue tabriz university of medical sciences - School of Medicine - Department of Physiology, تبريز, ايران , Soleimannejad, Elaheh Pasteur Iinstitute of Iran - Department of Physiology, تهران, ايران , Rashidi, Bahman isfahan university of medical sciences - School of Medicine - Department of Anatomy and Histology, اصفهان, ايران
Abstract :
BACKGROUND: The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats. METHODS: After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated. RESULTS: The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups. CONCLUSIONS: The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.
Keywords :
Diabetes , Glutamate , GABA , Dentate Gyrus , Treadmill Running , Microdialysis , Hippocampus , Strepto , zotocin
