Author/Authors :
el mongy, naglaa n. cairo university - kasr al ainy teaching hospital - department of dermatology, Cairo, Egypt , hilal, rana f. cairo university - kasr al ainy teaching hospital - department of dermatology, Cairo, Egypt , badr, amul m. cairo university - kasr al ainy teaching hospital - department of biochemistry, Cairo, Egypt , alraawi, samah a. cairo university - kasr al ainy teaching hospital - department of dermatology, Cairo, Egypt
Abstract :
Background Warts are a benign epithelial proliferation of the skin and mucosa that are caused by infection with human papillomavirus. Topical and intralesional vitamin D administrations were used in treating viral warts, suggesting the important role of vitamin D in viral warts. Objective To evaluate the serum levels of 25-hydroxyvitamin D (25-OHD) in Egyptian patients diagnosed with viral warts as compared with healthy controls to investigate the potential role of vitamin D in the viral warts. Patients and methods This case–control study included 40 patients with viral warts and 47 age-matched and sex-matched healthy controls. Blood samples were taken from all participants for the detection of serum 25-OHD levels by enzyme-linked immunosorbent assay. Results The present study showed a statistically significant decrease in the serum 25-OHD levels in patients with viral warts when compared with controls (P =0.001). In addition, there was a statistically significant difference between patients and controls regarding vitamin D status (P =0.001), as patients with viral warts had a more deficient pattern of vitamin D status than controls. Conclusion The present study showed significantly low levels of serum vitamin D in patients with viral warts, explaining the role of vitamin D in topical and intralesional therapy.
