Author/Authors :
Canbaz, Fevziye Ondokuz Mayıs University Hospital - Department of Nuclear Medicine - Samsun, Turkey , Aydın, Murat Ondokuz Mayıs University Hospital - Department of Pediatric Endocrinology - Samsun, Turkey , Meydan, Bilge Can Ondokuz Mayıs University Hospital - Department of Pathology - Samsun, Turkey , Bilgici, Meltem Ceyhan Ondokuz Mayıs University Hospital - Department of Pediatric Radiology - Samsun, Turkey , Arıtürk, Ender Ondokuz Mayıs University Hospital - Department of Pediatric Surgery - Samsun, Turkey
Abstract :
Nesidioblastosis”, later renamed as “persistent hyperinsulinemic hypoglycemia of infancy” presents as either focal or diffuse neo-differentiation of pancreatic Langerhans islet cells from the ductal epithelium. Differentiation of focal disease from diffuse involvement is crucial for optimal disease management. The current methods used to differentiate the two forms pre-operatively are invasive techniques. The definite role of imaging modalities to differentiate diffuse versus focal form has not yet been proven. Herein, we report a 15 day-old infant having diffuse nesidioblastosis, successfully demonstrated by Ga-68 DOTATATE positron emission tomography/computed tomography imaging that was histopathologically confirmed.
Keywords :
Ga-68 DOTATATE PET/CT , hyperinsulinemic hypoglycemia , Nesidioblastosis , differential diagnosis
