Author/Authors :
Kanda، Yoshinobu نويسنده , , Oshima، Kumi نويسنده , , Nannya، Yasuhito نويسنده , , Kaneko، Makoto نويسنده , , Hamaki، Tamae نويسنده , , Suguro، Miyuki نويسنده , , Yamamoto، Rie نويسنده , , Chizuka، Aki نويسنده , , Matsuyama، Tomohiro نويسنده , , Takezako، Naoki نويسنده , , Miwa، Akiyoshi نويسنده ,
Abstract :
We studied clinical features and pathologic findings in 52 consecutively autopsied patients with multiple myeloma in our center between 1979 and 1998. Distant extraosseous involvement was found in 33 patients (63.5%). Thirty-one patients (59.6%) were proven to have infection at autopsy, among which pneumonia was most common site of infection. Amyloidosis was shown in 8 patients. Second malignancies were observed in 4 cases. The three major causes of death were hemorrhage, infection, and renal failure, which accounted for death in approximately 70% of the patients. Advances in the anticancer and antimicrobial chemotherapies might have decreased deaths due to myeloma itself or infection.
