AN EVALUATION OF SELECTED LIPID PARAMETERS IN PREGNANCY COMPLICATED BY GESTATIONAL DIABETES MELLITUS

OBJECTIVE: To evaluate different parameters of lipid metabolism serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) in women with gestational diabetes mellitus (GDM). METHODS: This case-control study was conducted at Department of Obstetrics and Gynecology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine Metabolic Diseases (BIRDEM) Hospital from January 2009 to December 2009. Sixty (36 GDM and 24 healthy) pregnant women at rd their 3 trimester, selected by convenient-sampling method were included in the study. Data was collected by a structured questionnaire and analyzed by SPSS-22. RESULTS: Mean age was 30.05±5.62 years and 28.87±4.17 years in patients with GDM and without GDM respectively. Mean fasting blood sugar in patients with GDM was 8.27±2.5 mmol/L as compared to 4.9±.71 mmol/L in non- GMD group (p 0.001). Mean blood sugar after 2 hours of 75-gram oral glucose tolerance test was 12.62±2.1 mmol/L and 6.28±3.1 mmol/L in GDM non- GDM patients respectively (p 0.05). The lipid profile in GDM was found to be altered than those of healthy pregnant women in general. There was no statistically significant difference in serum TC, LDL-C in both groups. Serum TG level was found to be statistically higher and HDL-C level was statistically lower in GDM women comparing to healthy pregnant women (p 0.05). CONCLUSION: The lipid profile in GDM found to be altered than the healthy pregnant women. TG level was higher in GDM and HDL-C level was lower in GDM than in healthy pregnant women.