Title of article :
Synthesis, characterisation and biological activity of organotin derivatives of diclofenac sodium
Author/Authors :
ASHHAD HALIMI, SYED MOHAMMAD Government Medicines Co-ordination Cell, at L. R. Hospital, Pakistan , UL-ISLAM, NAZAR University of Peshawar - Department of Pharmacy, Pakistan , SAEED, MOHAMMAD International Islamic University Malaysia - Kulliyyah of Pharmacy, Malaysia
Abstract :
Two organotin complexes, trimethyltin and diphenyltin with diclofenac sodium as ligand, were prepared. Structure elucidation of the complexes prepared was carried out by infrared, multi nuclear magnetic resonance and mass spectroscopy. The spectral data suggest that trimethyltin diclofenate is four coordinate tetrahedral monomer while diphenyltin bis (diclofenate) retained its hexa coordinated octahedral geometry in solution. The biological activity of these two complexes proved to be powerful biocides
Keywords :
Organotin derivatives , Diclofenac sodium , Spectroscopic techniques , Antifungal activity
Journal title :
Malaysian Journal of Pharmaceutical Sciences
Journal title :
Malaysian Journal of Pharmaceutical Sciences
