Author/Authors :
Erem, Cihangir Karadeniz Technical University - Faculty of Medicine - Departments of Internal Medicine, Division of Endocrinology and Metabolism, Turkey , Yücel, Yusuf Karadeniz Technical University - Faculty of Medicine - Departments of General Surgery, Turkey , Yas¸ar, Ziya Karadeniz Technical University - Faculty of Medicine - Departments of Radiology, Turkey , Reis, Abdülkadir Karadeniz Technical University - Faculty of Medicine - Department of Pathology, Turkey , Kocak, Mustafa Karadeniz Technical University - Faculty of Medicine - Departments of Internal Medicine, Division of Endocrinology and Metabolism, Turkey , Hacıhasanoglu, Arif Karadeniz Technical University - Faculty of Medicine - Department of Internal Medicine, Division of Endocrinology, Turkey
Abstract :
Objective: We report a case of leukocytoclastic vasculitis as a manifestation of propylthiouracil hypersensitivity. Clinical Presentation and Intervention: A 66-year-old woman with a history of a toxic adenoma was referred for evaluation of a purpuric rash on the legs and buttocks bilaterally. She was biochemically hyperthyroid. Biopsy of the skin lesions revealed leukocytoclastic vasculitis. Propylthiouracil therapy was discontinued, and methimazole started. The purpuric rash resolved and surgical treatment for toxic adenoma resulted in euthyroid state. Conclusion: This report indicated that leukocytoclastic vasculitis should be considered in the differential diagnosis of patients with a vasculitic rash. The discontinuation of the propylthiouracil was associated with disappearance of the lesions.
