Genetic Variation in the Renin-Angiotensin System and Response to Endurance Training

Objective: To investigate the relationship between genetic variation in the renin-angiotensin system and the effect of 12-week endurance training in Korean women. Materials and Methods: Seventeen women who participated in an endurance training program for 12 weeks were genotyped for the angiotensinogen M235T polymorphism, angiotensin II type 1 receptor A1166C polymorphism, angiotensin-converting enzyme (ACE) T-3892C polymorphism, and angiotensin II type 2 receptor C3123A polymorphism. The following clinical parameters were measured before and after the endurance training program: blood pressure, body composition, ventilatory response, total cholesterol, triglyceride, and glucose. Results: Of the genetic markers investigated, the frequency of the T allele for the ACE T-3892C polymorphism was significantly associated with the response in body mass index and VO2max after 12 weeks of endurance training (p 0.05). None of the other polymorphisms were significantly associated with the effect of training. Conclusion: The significant association between ACE T-3892C and the change in body mass index and VO2max in Korean women are attributed to training, suggesting that this genetic variation is a useful genetic marker for clarifying the interindividual response to endurance training.