Title of article :
Thyroid Stimulating Hormone Receptor
Author/Authors :
Tuncel, Murat Hacettepe University Faculty of Medicine - Department of Nuclear Medicine - Ankara, Turkey
Abstract :
Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial role in tumor growth, which is initiated by several oncogenes. This article will provide a brief review of TSHR and related diseases.
Keywords :
adenoma , epigenetic alteration , thyroid cancer , Thyroid stimulating hormone receptor , genetic
Journal title :
Molecular Imaging and Radionuclide Therapy
