The impact of oxidative stress on Glucose-6-Phosphate Dehydrogenase level and prevalence of anemia among diabetic patients

Objective: The present study was conducted to assess the impact of oxidative stress on glucose 6 phosphate dehydrogenase (G6PD) and prevalence of anemia among diabetic patients. Methodology: The study involved 100 adult patients attending Buraidah Central Hospital and 30 healthy controls. Blood samples were collected and analyzed for (G6PD) activity, total antioxidant status (TAS), fasting blood sugar (FBS), hemoglobin (HGB), red cell( RBCs) count, hematocrit (HCT), mean cell volume (MCV), mean cell hemoglobin (MCH), and mean cell hemoglobin concentration (MCHC), hemoglobin A1c (Hb A1c), blood urea, serum creatinine, and microalbuminuria. Results: It showed significant correlation between G6PD deficiency and low TAS among diabetics and significant correlation between low hemoglobin concentration (females 120 g/L, males 130 g/L), G6PD deficiency and low concentration of TAS. The prevalence of anemia was 22% in diabetics. Conclusion: It can be concluded that there is significant impact of oxidative stress (reduced TAS) on reduced G6PD level and the low HGB concentration in diabetic patients, that means oxidative stress of diabetes mellitus is possible cause of G6PD anemia.