Association of genetic polymorphisms at the glutathione S-transferase Pi locus with prostate cancer

Objective: The present report evaluates a possible association of the GST-pi Ile105Val polymorphism with sporadic prostate cancer. Methodology: Tissue samples from 35 prostate adenocarcinomas and 26 geographically and age matched benign prostatic hyperplasia (BPH) patients as control subjects were tested for GST-pi polymorphism by using restriction fragment length polymorphism (RFLP) method for the polymerase chain reaction (PCR) product. Results: Among prostate carcinoma patients, 60% were homozygous for the wild type allele (Ile/Ile), 22% for heterozygous (Ile/Val) and 18% homozygous for mutant allele (Val/Val). While, the control group showed 64% of the subjects were homozygous for wild type allele, 28% were heterozygous and 8% homozygous for mutant allele. Conclusion: Val/Val genotype of GST-pi was significantly connected with prostate cancer risk, hence, GST-pi polymorphism may take part in developing prostate cancer.