Risk factors of cardiovascular disease in patients with renal transplantation

Objective: This study aims to observe the risk factors of cardiovascular disease in patients after kidney transplantation. Methods: Total 102 patients after renal transplantation (group A) and 96 clinic examination cases (group B) were recruited. Blood pressure, blood urea nitrogen (BUN) and creatinine (Cr), blood glucose (GLU), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein A-I ( apoA-I ) of the subjects were tested. These indexes were tested 3 times in group A in the 1, 2, and 3 month after kidney transplantation surgery. Electrocardiogram examination was done in the third month after kidney transplantation surgery. Results: There were significant differences in the incidence of hypertension, hyperglycemia and dyslipidemia between the two groups. After operation, the levels of BUN and Cr decreased significantly in 57 cases of group A without taking antihypertensive drugs (P 0.01). However, there was no significant difference in the blood pressure regardless of the systolic blood pressure (SBP) and diastolic blood pressure (DBP) before and after operation. In group A, the abnormal rate of ECG was 65%, the incidence of ST-T changes, prolongation of QT interval, left ventricular hypertrophy and left ventricular high voltage increased significantly (P 0.01). Conclusion: The incidence of coronary heart disease risk factors such as hypertension and hyperglycemia are high in patients after renal transplantation.